Arizona's Week 1 depth chart vs. New Orleans signals a shakeup-filled opener: Kyler Murray and Jacoby Brissett quarterback the offense, with James Conner leading a multi-weapon backfield featuring Trey Benson and Emari Demercado. Marvin Harrison Jr., Zay Jones, Xavier Weaver and Michael Wilson headline a new-look receiving corps, while Paris Johnson Jr. anchors the line alongside Kelvin Beachum and Evan Brown. A rookie on defense adds intrigue as the Cardinals aim to outpace the Saints.

From the trenches to the secondary, the Cardinals lean on versatile pieces like Zaven Collins and Owen Pappoe in the middle, and Calais Campbell pairs with Dalvin Tomlinson to pressure Saints QB Derek Carr. Special teams feature Chad Ryland as kicker in a game where field position could tip fantasy leverage. Expect individualized upside for several pass-ccatchers and a floor-boosted Murray rushing floor in a pivotal Week 1.