The Arizona Cardinals face a significant challenge as starting cornerback Sean Murphy-Bunting has been placed on the reserve/non-football injury list, jeopardizing his 2025 season. Murphy-Bunting, who contributed with three interceptions and five passes defended last year, is now sidelined, adding pressure to the team's defensive backfield.

In his absence, the Cardinals will rely on a mix of young talent, including second-round draft picks Will Johnson and Max Melton, along with Garrett Williams, who was drafted in the third round. The team is also exploring available veteran cornerbacks in free agency to bolster their secondary.