Tampa Bay opened 2025 with two road wins, sitting atop the NFC South as Bowles and Mayfield push a high-tempo attack forward. It’s the third straight 2-0 start for the duo, a rare streak, but midseason slumps remain a recurring risk. With injuries lingering, the schedule turns brutal: Jets, Eagles, Seahawks, 49ers, Lions will test sustainability. Fantasy notes point to Week 3 pickups Romeo Doubs and Zach Ertz, plus mentions of a Vikings running back reunion and a Texas Tech–Utah NFL Draft duel shaping wider fantasy angles.

Arizona's injury-riddled secondary tests the coaching staff as Will Johnson's groin status remains uncertain after Week 2. The Cardinals have also lost Max Melton, Garrett Williams, Sean Murphy-Bunting, and Starling Thomas, with Walter Nolen sidelined for at least four weeks. A brutal stretch ahead includes a road game at San Francisco followed by a Thursday night showdown with Seattle, forcing rookies to step up quickly.

Kyler Murray emphasized readiness and resilience, underscoring the domino effect of the injuries. For fantasy managers, monitor practice reports for depth chart shifts and potential increases in targets or role changes in the secondary as Arizona looks to weather the storm.

Bills sit No. 1 with a clean Week 2 showing, followed by Eagles, Ravens, Packers, and Chargers as Week 3 favorites. The rest of the league shifts with the Dolphins and Panthers sliding after rough outings, while Colts climb into the middle of the pack on explosive offense and emerging pieces. Bryce Young flashed in Carolina, Spencer Rattler impressed in New Orleans, and J.J. McCarthy looks like a work-in-progress in Minnesota as teams settle into schemes and fantasy roles.

Jauan Jennings played Week 2 through an ankle and shoulder issue, catching 5 of 10 targets for 89 yards and a touchdown while logging 87% of snaps. With George Kittle sidelined or limited, Week 3 vs Arizona could push Jennings for meaningful volume, provided the ankle remains minor. He’s listed day-to-day but is expected to play, offering upside as a high-variance flex option.

Key risk is the ankle flare; if Jennings suits up, he’s a volatile but potentially rewards-heavy play in deep leagues. Monitor Sunday updates and consider Jennings as a boom-or-bust flex with the upside to exploit a Cardinals defense that has shown vulnerability to pass-heavy schemes.