Week 2 DFS spotlight centers on five RB matchups: Gibbs vs Bears, McCaffrey vs Saints, Conner vs Panthers, Hall vs Bills, Williams vs Cowboys. The focus is on game-script independent backs who can reach 15-20 touches regardless, a rarity in today’s NFL.

The Lions look to rebound at home while Chicago’s run defense isn’t as stout as last year. Arizona and San Francisco lean on their respective lead backs, with New York’s duo in a favorable grind. These spots fuel DFS lineups, season-long builds, and prop bets alike.

McMillan steps into Week 2 as Carolina's clear target, delivering a stable WR2 floor despite a modest Week 1. He drew 9 targets, turning them into 68 yards with elite downfield involvement (14.7 aDOT, 47.1% air yards). The matchup with Arizona is decent; Young’s early chemistry with McMillan keeps him in lineups in all formats.

The Week 1 Cardinals game plan allowed over 214 passing yards to Spencer Rattler, paving a path for McMillan to continue earning looks and maintaining volume. Expect Carolina to lean on the rookie as a primary downfield weapon, keeping McMillan firmly in the weekly WR2 mix with modest but real upside if the offense converges on rhythm.

Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.