Tampa Bay opened 2025 with two road wins, sitting atop the NFC South as Bowles and Mayfield push a high-tempo attack forward. It’s the third straight 2-0 start for the duo, a rare streak, but midseason slumps remain a recurring risk. With injuries lingering, the schedule turns brutal: Jets, Eagles, Seahawks, 49ers, Lions will test sustainability. Fantasy notes point to Week 3 pickups Romeo Doubs and Zach Ertz, plus mentions of a Vikings running back reunion and a Texas Tech–Utah NFL Draft duel shaping wider fantasy angles.

Seattle's cornerback room has evolved into a standout trio—Riq Woolen, Devon Witherspoon and Josh Jobe—as Tre Brown exits for in-division shuffle and depth moves. Brown’s one-year stint with Seattle ended after a 49ers stint and a heel injury; the Rams then added him to bolster depth behind an injured Ahkello Witherspoon. Seattle’s eyes stay on a young, athletic unit, while the Rams, and to a degree the 49ers, hint at NFC West pass-defense volatility with fantasy implications.

Arizona's injury-riddled secondary tests the coaching staff as Will Johnson's groin status remains uncertain after Week 2. The Cardinals have also lost Max Melton, Garrett Williams, Sean Murphy-Bunting, and Starling Thomas, with Walter Nolen sidelined for at least four weeks. A brutal stretch ahead includes a road game at San Francisco followed by a Thursday night showdown with Seattle, forcing rookies to step up quickly.

Kyler Murray emphasized readiness and resilience, underscoring the domino effect of the injuries. For fantasy managers, monitor practice reports for depth chart shifts and potential increases in targets or role changes in the secondary as Arizona looks to weather the storm.

Bills sit No. 1 with a clean Week 2 showing, followed by Eagles, Ravens, Packers, and Chargers as Week 3 favorites. The rest of the league shifts with the Dolphins and Panthers sliding after rough outings, while Colts climb into the middle of the pack on explosive offense and emerging pieces. Bryce Young flashed in Carolina, Spencer Rattler impressed in New Orleans, and J.J. McCarthy looks like a work-in-progress in Minnesota as teams settle into schemes and fantasy roles.