Thursday Night Football features a high-profile NFC West showdown as the Los Angeles Rams host the San Francisco 49ers. Kyren Williams is the Rams’ likely bellcow, with Christian McCaffrey carrying heavy workload for SF. The top anytime TD picks center Williams (-185) and Davante Adams (+115), with Marquez Valdes-Scantling a long shot (+1300). Purdy (toe) and Pearsall (knee) hover as injury risks that could boost Nacua’s target share in LA. The piece highlights sharp bets and promos across DraftKings, FanDuel, and BetMGM, plus a +4300 parlay to chase big upside.

Rams vs. 49ers on Thursday Night Football centers on Kyren Williams and Christian McCaffrey as lead backs. Williams has TDs in 23 of 32 games and five scores in three career matchups with SF, including last season at SoFi. McCaffrey is slated for another heavy workload for the 49ers.

Model-based picks lean Williams -185 to score, with Adams +115 and Valdes-Scantling +1300. Williams offers the safest TD floor; Adams brings upside if his hamstring cooperates. Parlay potential runs to +4300 with current promos.

Ricky Pearsall's knee issue clouds San Francisco's Week 4 plan vs. Jacksonville. He didn’t practice Wednesday and logged limited sessions Thursday and Friday; the 49ers need him, but his availability is still uncertain. If Pearsall plays, he’s a viable WR3/flex in many setups. If he sits, Marquez Valdes-Scantling, Sky Moore, and Kendrick Bourne would absorb more snaps and targets, yet none emerge as a clear weekly floor behind Christian McCaffrey. Purdy’s return from a toe injury adds stability to the passing game.

The Jaguars have allowed the ninth-most fantasy points to wide receivers, but analytics paint a more nuanced picture: seventh in DVOA and sixth in EPA per pass attempt allowed. With Pearsall active, expect a healthy 49ers passing attack to share targets; with him out, relief options become speculative. Expect McCaffrey to remain the primary focal point regardless. Jennings is also questionable, which could further shape Week 4 decisions.