Sam Darnold dazzled Seattle with 341 passing yards and four touchdowns, but two late miscues cost the Seahawks in a 38-35 loss to Tampa Bay. A final-minute interception followed a scramble pressure sequence and a topper to Lavonte David off a deflection, sealing the defeat after Seattle had rolled five straight scoring drives. The Week 1 fumble at Lumen Field looms as another reminder that late-game ball security remains a responsibility.

Fantasy managers must weigh Darnold's explosive ceiling against the risk of crunch-time miscues. Seattle's offense flashed, AJ Barner remains a trusted target, and the Seahawks sit at 3-2 as they gear up for the next challenge.

Week 5 starts hinge on volume and matchup. Rachaad White steps into the lead back role for Tampa Bay with Bucky Irving out, offering solid flex upside in a favorable matchup vs Seattle. Pollard remains the Titans’ workhorse until Tyjae Spears returns, keeping him in flex territory. Kenneth Walker III faces a stout run defense and a backfield committee, making him a low-end RB2 with punt-punt upside via receiving work. Keenan Allen projects heavy targets against Washington, while Calvin Ridley and Ja’Marr Chase remain high-end options in shootouts. Sean Tucker is a speculative stash behind White, Luke McCaffrey’s role is uncertain, and Cooper Kupp stands as a must-start.

Overall, the Week 5 landscape favors high-volume pass-catchers and disciplined runners in clear roles. The Who Should I Start tool helps parse four-player comps, factoring scoring formats and byes to surface the best starts. Monitor injuries and game-flow specifically for Spears, Irving, and any last-minute Washington adjustments for Allen and Ridley, then lock in your lineup with confidence.

Injuries forced San Francisco into unfamiliar roles, but they beat Los Angeles 26-23 to seize the NFC West lead. Alfred Collins forced and recovered a goal-line fumble, and Kendrick Bourne piled up 142 yards on 10 catches as Mac Jones steered the offense in Purdy's toe-injury absence.

Stafford threw for 389 yards and 3 TDs, but the Rams stalled late; Kyren Williams fumbled near the goal line, and Puka Nacua kept the air busy with 10 receptions for 76 yards and a TD. The 49ers’ defense held on a crucial OT stop, setting up a Week 6 clash with Tampa Bay.