Week 5 kicks off with Rams at 49ers in a pivotal NFC West showdown on Thursday Night Football. Matthew Stafford and Puka Nacua have fueled the Rams, with Nacua leading the league in receptions and receiving yards. San Francisco heads in shorthanded at quarterback and receiver after a loss, but owns a top-tier pass defense. Rams are 8-point favorites with a 45.5 over/under; Stafford’s prop sits around 240.5 passing yards. Fanatics promo adds gameday FanCash.

Three Week 5 waiver-wire targets lead Week 5 at kicker: Spencer Shrader, Jason Myers and Matt Gay. Shrader has been Indy’s most reliable fantasy leg, supported by the Colts’ league-best offense and Lucas Oil’s indoor climate, setting up a favorable home date with Las Vegas. Myers has posted back-to-back double-digit weeks for Seattle, including a 52-yard late winner vs Arizona, as Seattle faces Tampa Bay. Gay resurfaced for Washington with four makes and 18 points, heading to Los Angeles for a Chargers test.

All three offer clear Week 5 upside, with Shrader as the strongest floor play, Myers as a steady late-game option in a competitive NFC, and Gay showing long-range upside in indoor venues. Rosters should target Shrader first, then Myers, then Gay, depending on matchup and venue weather.

Seahawks win on a 52-yard late field goal as Week 4 opened with drama in Seattle. The weekend featured the Packers and Cowboys trading blows into OT, a breakout by Jaxson Dart in his first Giants start, and the Rams’ late-nigh surge led by Puka Nacua’s relentless targets. San Francisco’s stumble against Jacksonville exposed some flaws, while Kansas City pressed on, and the rookie wave continued with standout debuts and breakout performances across the league. Fantasy angles loom as teams begin settling into the season’s early rhythm.

Rising storylines include Nacua’s historic early production, the Rams balancing offense with Herbert’s Chargers, and injuries testing depth across rosters. The Patriots reshaped their backfield usage, the Bears’ late momentum bought a bye-week spark, and the Titans’ struggles raised red flags. With byes on the horizon, this week highlighted who can sustain fantasy value and who’ll need breakout opportunities to stay relevant.