Tyrese Knight’s return to practice and Tory Horton’s rising readiness push Seattle toward Week 1 with healthier inside linebacking next to Ernest Jones. Horton’s speed could boost Seattle’s return game and short-area offense as Seattle leans on Kenneth Walker III and Zach Charbonnet to pressure San Francisco early. San Francisco counters with McCaffrey and Kittle, while Brock Purdy tests Seattle’s interior rush in a game where Leonard Williams and Dominick Puni must collapse the middle.

Key fantasy takeaways center on Seattle’s RB split, Knight’s health impact, and Seattle’s ability to ground SF’s run game to open play-action chances for Darnold and Purdy. Meanwhile, Cross and Lucas must neutralize Nick Bosa, and Seattle’s WRs—particularly Jackson Smith-N Jigba—will need to beat a relatively inexperienced 49ers secondary.