Seattle travels to Pittsburgh in Week 2 with a sharpened focus on the run game while facing a Steelers defense still adapting to zone looks after offseason tweaks. The absence of first-round tackle Derrick Harmon heightens interior concerns for Pittsburgh, elevating the importance of edge and secondary play to slow Seattle’s attack and keep DK Metcalf in check through versatile coverage.

Josh Jobe’s size and speed could be the pivotal matchup when Metcalf lines up on the boundary, potentially shaping where Seattle routes its best contested catches. This clash of run-first schemes and cover-2 tendencies will influence early-season fantasy value on both sides as the game unfolds at Acrisure Stadium.

In a Week 2 spotlight, depth, matchup wins and playmaking will determine which offense gains the upper hand, with Metcalf and Jobe serving as the marquee one-on-one stories and Harmon’s absence quietly reframing the Steelers’ interior pressure plan.