Seattle’s Week 2 outlook centers on health in the secondary. Devon Witherspoon sat Wednesday with a knee DNP after a late collision in Week 1, while Uchenna Nwosu and Jake Bobo practiced in full, hinting at a possible return. Nick Emmanwori appears headed for an IR stint with a high-ankle sprain. Pittsburgh’s DeShon Elliott is unlikely to play, andkj Camden? Watch for changes as Jobe and Woolen could shoulder more coverage.

Fantasy implications hinge on Witherspoon’s status: if he sits, Seattle’s corner depth could be tested, potentially lifting short-term targets for Steelers pass-catchers. If Spoon plays, Seattle’s defense stabilizes and WRs like Bobo become more viable in deeper formats. Nwosu’s potential return could boost Seattle’s rush, while Emmanwori’s absence tightens safety depth.

Seattle’s Week 1 inactive list reshapes the Seahawks’ game plan against San Francisco, with Bobo, Dareke Young and Uchenna Nwosu among seven SEA players out. The 49ers also rolled seven, trimming depth at multiple spots. Expect increased opportunities for Seattle’s top receivers and for linebackers stepping into larger roles, as both teams adjust to missing contributors in a considered Week 1 matchup.

Key Seahawks absences include Bobo and Young at wide receiver and Nwosu on the edge, while the 49ers sit several depth players to open the door for others. In fantasy terms, the biggest shifts come from who absorbs the extra targets and snaps on SEA’s offense and who gains reps in SF’s depth chart, potentially altering streamer and DFS value in a marquee Week 1 battle.

Seattle elevated Shaquill Griffin and Quinton Bohanna from the practice squad ahead of Week 1 against San Francisco, a move that tightens Seattle’s front-line depth after a thin interior rotation and several injuries. Bohanna faces limited expectancies unless interior injuries mount, while Griffin’s return gives veteran cover at cornerback as Seattle copes with injuries to Johnathan Hankins and Rylie Mills in the middle. With Jake Bobo and Dareke Young ruled out, Seattle’s four active receivers are Jaxon Smith-Njigba, Cooper Kupp, Tory Horton Jr., and Cody White, creating a high-leverage Week 1 target situation for JSN and an unsettled WR mix for fantasy rosters. Uchenna Nwosu is also out, further stressing the edge and overall pass rush plan.

Seattle's Week 1 build is thinning at wide receiver. Bobo is sidelined by concussion, Tory Horton ankle, Cody White shoulder, and Dareke Young hamstring, with Horton practicing fully later in the week. Uchenna Nwosu is ramping up but not yet ready. Seattle has just six WR on the active roster, leaving depth questions for the 49ers defense. Jaxon Smith-Njigba and Cooper Kupp are noted as the players not on the initial injury report.

The Seahawks could lean on practice-squad options Ricky White III, Courtney Jackson, and Tyrone Broden if needed. Tyrice Knight’s knee absence is notable but he looks set to play, a big boost for the defense. Injury updates roll out Thursday and Friday ahead of Sunday’s 1:05 p.m. kickoff at Lumen Field.