Joe Mixon’s 2025 season is in limbo. The Texans placed him on the non-football injury list and he has not practiced since mid‑July, with no clear return date. In his absence, Houston has leaned on Nick Chubb, while Dare Ogunbowale, Dameon Pierce and rookie Woody Marks handle depth duties. For fantasy managers, hold Mixon in IR spots if possible, but be prepared to pivot in shallow leagues as a late-season return remains uncertain.

Buffalo Bills host the Miami Dolphins in Thursday Night Football as Week 3 opens, with Buffalo riding a 2-0 start and Miami slumping 0-2. Bills are the heavy -13.5 favorite, and the slate features two undefeateds in Philly vs Los Angeles and Arizona vs San Francisco. Giants vs Chiefs caps Sunday Night, while Lions visit Ravens on Monday Night Football. The full card lists every Week 3 game with lines, totals, and FPI odds to guide fantasy lineups and bold bets.

Fantasy emphasis centers on exploiting high-scoring expectancies and favorable game scripts. Track line moves and totals for starts like top offenses and potential shootouts, while identifying mid-range sleepers in games with clear target volume or pace advantages. Use the odds and projections to balance upside with risk as Week 3 decisions tighten.

Geno Smith lands in Las Vegas after a bargain trade, with Chip Kelly running the show and the Raiders counting on a steady, high-football-IQ quarterback. Week 1 suggested a fit: quick reads, minimal turnovers, and a command of Kelly’s install that could lift the entire offense after years of quarterback churn.

Against the Chargers, expect a balanced plan with short, precise passes that drive sustained drives; his decision-making could keep him in QB2 territory with weekly upside.