Seattle travels to Pittsburgh in Week 2 with a sharpened focus on the run game while facing a Steelers defense still adapting to zone looks after offseason tweaks. The absence of first-round tackle Derrick Harmon heightens interior concerns for Pittsburgh, elevating the importance of edge and secondary play to slow Seattle’s attack and keep DK Metcalf in check through versatile coverage.

Josh Jobe’s size and speed could be the pivotal matchup when Metcalf lines up on the boundary, potentially shaping where Seattle routes its best contested catches. This clash of run-first schemes and cover-2 tendencies will influence early-season fantasy value on both sides as the game unfolds at Acrisure Stadium.

In a Week 2 spotlight, depth, matchup wins and playmaking will determine which offense gains the upper hand, with Metcalf and Jobe serving as the marquee one-on-one stories and Harmon’s absence quietly reframing the Steelers’ interior pressure plan.

Josh Jobe’s Week 1 breakout anchors Seattle’s secondary: five targets, one yard allowed, and a second interception, complemented by a 71.4% lockdown rate and a top-tier 90.2 coverage grade. Will Johnson delivered a poised rookie debut for Arizona, allowing 32 yards on seven targets with three incompletions. Sauce Gardner opened with lockdown numbers while Jamel Dean and Javon Bullard handled heavy workloads. Garrett Williams and Johnson hint at a high-upside Cardinals duo, underscoring early-season edge Week 1 data can offer for fantasy CB decisions.

Seattle’s Week 2 outlook centers on health in the secondary. Devon Witherspoon sat Wednesday with a knee DNP after a late collision in Week 1, while Uchenna Nwosu and Jake Bobo practiced in full, hinting at a possible return. Nick Emmanwori appears headed for an IR stint with a high-ankle sprain. Pittsburgh’s DeShon Elliott is unlikely to play, andkj Camden? Watch for changes as Jobe and Woolen could shoulder more coverage.

Fantasy implications hinge on Witherspoon’s status: if he sits, Seattle’s corner depth could be tested, potentially lifting short-term targets for Steelers pass-catchers. If Spoon plays, Seattle’s defense stabilizes and WRs like Bobo become more viable in deeper formats. Nwosu’s potential return could boost Seattle’s rush, while Emmanwori’s absence tightens safety depth.

Seattle’s Riq Woolen faces a Week 2 quandary as Mike Macdonald weighs starting Dante rotation and the return of Devon Witherspoon. Woolen, who has started 47 of 49 since 2022 and earned Pro Bowl honors as a rookie, showed volatility in Week 1, surrendering two pivotal plays including the 49ers’ game-winner. Seattle also has Josh Jobe nipping at the boundary, and Witherspoon’s health could tilt snaps toward Jobe and Witherspoon on Sunday vs. Pittsburgh. Woolen’s role, though, has fluctuated before, and Macdonald has adjusted him before, making his Week 2 outlook cloudy but still influential for fantasy.

Two things loom: Woolen’s role could re-enter as a starter if the others aren’t fully ready, yet a healthy Witherspoon and a rising Jobe could cap Woolen’s ceiling. The Nick Emmanwori injury will keep Woolen involved, though not on every snap. In short, Woolen remains a high-variance hold with upside if workload lines up, while Jobe/Witherspoon present plausible rejection of a full-time role depending on health and performance.