Seattle's Week 1 focus is defense-first, with a revamped unit under Mike Macdonald and a healthy front that should pressure opponents. Offense remains a work in progress, facing interior-line questions and chemistry gaps with Darnold and the pass-catchers. Fantasy takeaway centers on Seattle's defense upside and rise of Jaxon Smith-Njigba as a top target, with Nwosu and the secondary stepping up as Week 1 high-upside plays.

Key figures include Uchenna Nwosu’s edge pressure, Devon Witherspoon and Byron Murphy II in the secondary, and Abraham Lucas stabilizing the line. If Seattle can protect, hit on play-action, and let JSN grow into the target share, the offense could carve out respectable fantasy value while the defense carries the team in several low-scoring games early in the season.