Seattle’s Week 1 inactive list reshapes the Seahawks’ game plan against San Francisco, with Bobo, Dareke Young and Uchenna Nwosu among seven SEA players out. The 49ers also rolled seven, trimming depth at multiple spots. Expect increased opportunities for Seattle’s top receivers and for linebackers stepping into larger roles, as both teams adjust to missing contributors in a considered Week 1 matchup.

Key Seahawks absences include Bobo and Young at wide receiver and Nwosu on the edge, while the 49ers sit several depth players to open the door for others. In fantasy terms, the biggest shifts come from who absorbs the extra targets and snaps on SEA’s offense and who gains reps in SF’s depth chart, potentially altering streamer and DFS value in a marquee Week 1 battle.

Seattle elevated Shaquill Griffin and Quinton Bohanna from the practice squad ahead of Week 1 against San Francisco, a move that tightens Seattle’s front-line depth after a thin interior rotation and several injuries. Bohanna faces limited expectancies unless interior injuries mount, while Griffin’s return gives veteran cover at cornerback as Seattle copes with injuries to Johnathan Hankins and Rylie Mills in the middle. With Jake Bobo and Dareke Young ruled out, Seattle’s four active receivers are Jaxon Smith-Njigba, Cooper Kupp, Tory Horton Jr., and Cody White, creating a high-leverage Week 1 target situation for JSN and an unsettled WR mix for fantasy rosters. Uchenna Nwosu is also out, further stressing the edge and overall pass rush plan.

Seattle's Week 1 build is thinning at wide receiver. Bobo is sidelined by concussion, Tory Horton ankle, Cody White shoulder, and Dareke Young hamstring, with Horton practicing fully later in the week. Uchenna Nwosu is ramping up but not yet ready. Seattle has just six WR on the active roster, leaving depth questions for the 49ers defense. Jaxon Smith-Njigba and Cooper Kupp are noted as the players not on the initial injury report.

The Seahawks could lean on practice-squad options Ricky White III, Courtney Jackson, and Tyrone Broden if needed. Tyrice Knight’s knee absence is notable but he looks set to play, a big boost for the defense. Injury updates roll out Thursday and Friday ahead of Sunday’s 1:05 p.m. kickoff at Lumen Field.

Seattle's Week 1 focus is defense-first, with a revamped unit under Mike Macdonald and a healthy front that should pressure opponents. Offense remains a work in progress, facing interior-line questions and chemistry gaps with Darnold and the pass-catchers. Fantasy takeaway centers on Seattle's defense upside and rise of Jaxon Smith-Njigba as a top target, with Nwosu and the secondary stepping up as Week 1 high-upside plays.

Key figures include Uchenna Nwosu’s edge pressure, Devon Witherspoon and Byron Murphy II in the secondary, and Abraham Lucas stabilizing the line. If Seattle can protect, hit on play-action, and let JSN grow into the target share, the offense could carve out respectable fantasy value while the defense carries the team in several low-scoring games early in the season.

Kansas City rests a cluster of veterans in Week 2 of the preseason against Seattle, clearing a path for depth players and late-round prospects to audition behind Hollywood Brown, Briningstool, Deon Bush, Janarius Robinson, Ethan Driskell, and Kareem Hunt. Seattle mirrors the strategy, listing Olu Oluwatimi, Josh Ross, Charles Cross, Kenny McIntosh, Johnathan Hankins, Uchenna Nwosu, and Tyrice Knight as not expected to play. In such games, the fantasy angles shift toward the players fighting for backups, special-teams roles, and breakout opportunities in a game-script that emphasizes depth over stars.

With Brown and Hunt sidelined, Chiefs reps at wideout and backfield become more unpredictable, elevating backup receivers and rotational backs into potential late-round fantasy dice rolls. Seattle’s inactive list creates a similar vacuum along the offensive line and linebacking corps, where a few veterans could be eased in or pushed to star in a run-heavy, evaluative environment. Those watching for fantasy return value should focus on the depth chart movers who flash in extended opportunities, as preseason reps often foreshadow emerging roles come the regular season.

Keep in mind preseason inactives are subject to change and aren’t formalized the same way as regular-season lists. Rosters and playing time can shift an hour before kickoff, underscoring the value of quickly updating projections as the game unfolds.