The San Francisco 49ers navigated a challenging season impacted heavily by injuries, particularly in their skill positions. Christian McCaffrey dealt with bilateral Achilles tendonitis that hindered his performance, affecting the run game significantly. Brandon Aiyuk also faced injuries that limited his contributions. The Niners' depth was tested as they struggled to maintain offensive consistency during crucial stretches of the season. Despite these setbacks, the team managed to leverage their defense and coaching strategies to remain competitive, but the lack of key players like McCaffrey in peak condition weighed heavily on their overall success.