George Kittle missed the rest of Week 1 with a hamstring injury and is headed to injured reserve, sidelining him for at least four games. He logged 4 targets, 4 receptions, 25 yards, and a touchdown before exiting, underscoring the 49ers’ reliance on him when healthy. San Francisco will lean on the TE trio of Luke Farrell and Jake Tonges to fill the void as Brock Purdy adjusts his target distribution.

Fantasy managers must rethink Kittle’s lofty ADP (around 34 overall) and pivot to plausible Week 2 waiver adds like Hunter Henry, Zach Ertz, Jonnu Smith, or Juwan Johnson, who could soak up extra work. The 49ers’ next stretch runs through Week 7, with a schedule that includes Saints, Cardinals, Jaguars, Rams, and Buccaneers, before Kittle’s return timeline, which Aaron-adjudicated sources suggest is more likely Week 7 than Week 6.

With Kittle out, Purdy’s tight end targets widen, and the 49ers’ offense will ramp up the run game and screen passes to compensate. Depth at tight end becomes a nightly decision point for fantasy rosters, and the waiver wire will be the battleground for Week 2 and beyond.

Undermanned but unflappable, San Francisco edged the Rams 26-23 as Mac Jones thrived with a patchwork receiving corps. Bourne logged 10 receptions for 142 yards, Jones threw for 342 yards and 2 TDs with no picks, and the defense closed it out with a late stand. Purdy is week-to-week, but Jones's showing keeps fantasy options alive behind SF's depth.