San Francisco’s Week 5 win over the Rams comes with a growing injury toll ahead of Week 6 vs Tampa Bay. Upton Stout’s ankle sprain isn’t high-grade, but it creates uncertainty in the 49ers’ secondary. Kalia Davis broke a hand and will undergo surgery, likely thinning interior push. Yetur Gross-Matos and Alfred Collins are limited by hamstring and knee injuries, respectively. Malik Mustapha’s ACL injury opens a 21-day practice window, while George Kittle is a distant (week-to-week) option for Week 6 with hopes for Week 7. SF will lean on depth as it prepares for the Buccaneers.

Injuries forced San Francisco into unfamiliar roles, but they beat Los Angeles 26-23 to seize the NFC West lead. Alfred Collins forced and recovered a goal-line fumble, and Kendrick Bourne piled up 142 yards on 10 catches as Mac Jones steered the offense in Purdy's toe-injury absence.

Stafford threw for 389 yards and 3 TDs, but the Rams stalled late; Kyren Williams fumbled near the goal line, and Puka Nacua kept the air busy with 10 receptions for 76 yards and a TD. The 49ers’ defense held on a crucial OT stop, setting up a Week 6 clash with Tampa Bay.

Undermanned but unflappable, San Francisco edged the Rams 26-23 as Mac Jones thrived with a patchwork receiving corps. Bourne logged 10 receptions for 142 yards, Jones threw for 342 yards and 2 TDs with no picks, and the defense closed it out with a late stand. Purdy is week-to-week, but Jones's showing keeps fantasy options alive behind SF's depth.

Alfred Collins’ goal-line strip and a sturdy late stand by the 49ers’ defense propelled San Francisco to a 26-23 win at Los Angeles, validating a defense-first blueprint even with a dented offense. The play preserved a potential turn-point moment after a shaky red-zone sequence and three straight runs to bleed clock kept the Rams out of reach in regulation.

SF moved to 4-1 atop the NFC West, buoyed by rookie contributors on defense and the prospect of healthier weapons returning—Jennings, Pearsall, and Kittle—while injuries continue to test the depth. The win could quiet the draft-grading chatter and hint that the Niners’ playmakers, not the picks, will carry them forward for fantasy rosters in the coming weeks.

Kalia Davis exited with a hand injury in the second quarter of San Francisco’s Thursday night clash with the Rams, compounding an injury-plagued start to 2025 for the 49ers. With Davis questionable and Kevin Givens on IR, San Francisco could lean on Jordan Elliott, Alfred Collins, C.J. West and rookie Mykel Williams to anchor the interior. The late update confirmed Davis will miss the rest of the game, forcing a deeper rotation and more sub-packages against L.A.