San Francisco’s Week 5 win over the Rams comes with a growing injury toll ahead of Week 6 vs Tampa Bay. Upton Stout’s ankle sprain isn’t high-grade, but it creates uncertainty in the 49ers’ secondary. Kalia Davis broke a hand and will undergo surgery, likely thinning interior push. Yetur Gross-Matos and Alfred Collins are limited by hamstring and knee injuries, respectively. Malik Mustapha’s ACL injury opens a 21-day practice window, while George Kittle is a distant (week-to-week) option for Week 6 with hopes for Week 7. SF will lean on depth as it prepares for the Buccaneers.

Postgame heat flared when Robert Saleh and Liam Coen exchanged heated words after Jacksonville’s 26-21 win, sparked by Saleh’s claim that the Jaguars «legally stealing signals» is a strength. Kyle Shanahan downplayed the moment, insisting Saleh meant a compliment and that nothing illegal was involved. Trevor Lawrence steered the Jaguars with restraint, aided by a plus-four turnover margin, while players and coaches kept focus on execution ahead of the next matchup.

Jacksonville handed the 49ers a 26-21 loss at Levi’s Stadium, and the postgame scene spilled over into a tense standoff as Robert Saleh and Liam Coen were restrained from exchanging hands. The incident added a dramatic subplots to an early-season matchup, with players and staffers nearby amplifying the moment.

Saleh had stirred chatter earlier in the week by praising Jacksonville’s signaling operation, prompting questions about whether the comment was mind games or a real edge for the Jaguars. Coen addressed the topic in his press conference, appearing annoyed by the lines of inquiry.

The scene featured Yetur Gross-Matos and others in the vicinity, and a handshake never materialized between the coaches as rivals left the field. The Jaguars earned the win and handed San Francisco its first loss, setting up an ongoing storyline about signaling and strategic edge that fantasy owners will be watching closely.