The 49ers’ Week 5 win over the Rams rode on a chaotic OT stop after a steady defensive push and a late, gritty performance by the squad’s supporting cast. Mykel Williams didn’t post a stat line but drew the eye with a game-changing edge step that opened the winning path for Warner, while Marques Sigle and Deommodore Lenoir held the back end together in a tense finish. Offensively, SF leaned on McCaffrey’s blocking and Purdy’s health narrative, with Mac Jones stepping in as a surprise producer in the quarterback shuffle. Trade chatter swirls around Hendrickson as the front office weighs a playoff push, and the team braces for Kittle’s potential absence while Malik Mustapha nears return. Fantasy takeaway: depth and health emerge as pivotal in a league where one big name can be out, one backup can step up, and defensive pressure can tilt outcomes in high-leverage moments.

Shanahan’s crew showed resilience, especially up front and in coverage, highlighting the IDP and streaming options for Week 6. Williams’ quiet stat line belies a fingerprints-on-the-game impact, while Sigle’s 13 tackles underscore the importance of safeties who can mix run support with coverage. The QB landscape remains fluid: Purdy’s health versus Jones’ hot run creates a dual-path for fantasy rosters, with Hendrickson potentially altering the defensive ceiling if a trade materializes. Monitor Kittle’s status, monitor Purdy’s health, and keep a pulse on the 49ers’ evolving depth chart as the schedule thickens.

Undermanned but unflappable, San Francisco edged the Rams 26-23 as Mac Jones thrived with a patchwork receiving corps. Bourne logged 10 receptions for 142 yards, Jones threw for 342 yards and 2 TDs with no picks, and the defense closed it out with a late stand. Purdy is week-to-week, but Jones's showing keeps fantasy options alive behind SF's depth.

San Francisco survived a Thursday with Purdy sidelined, Mac Jones thriving in relief, and a dramatic OT win over Los Angeles. Kyren Williams’ 4th-and-1 fumble loomed large, reshaping the late game, while the 49ers leaned on depth and defense as reinforcements prepare to return. The Rams still loom, but questions about red-zone calls and ball security linger as the NFC West race tightens.

Fantasy takeaways center on Williams’ reliability, Corum’s red-zone potential for LA, and SF’s risk-reward with Jones at the helm. Health will decide seeds—Kittle, Aiyuk, Pearsall, and Bosa looming back—keeping SF in the top mix while the Rams chase leverage in a tougher schedule.

Alfred Collins’ goal-line strip and a sturdy late stand by the 49ers’ defense propelled San Francisco to a 26-23 win at Los Angeles, validating a defense-first blueprint even with a dented offense. The play preserved a potential turn-point moment after a shaky red-zone sequence and three straight runs to bleed clock kept the Rams out of reach in regulation.

SF moved to 4-1 atop the NFC West, buoyed by rookie contributors on defense and the prospect of healthier weapons returning—Jennings, Pearsall, and Kittle—while injuries continue to test the depth. The win could quiet the draft-grading chatter and hint that the Niners’ playmakers, not the picks, will carry them forward for fantasy rosters in the coming weeks.