San Francisco’s Week 5 win over the Rams comes with a growing injury toll ahead of Week 6 vs Tampa Bay. Upton Stout’s ankle sprain isn’t high-grade, but it creates uncertainty in the 49ers’ secondary. Kalia Davis broke a hand and will undergo surgery, likely thinning interior push. Yetur Gross-Matos and Alfred Collins are limited by hamstring and knee injuries, respectively. Malik Mustapha’s ACL injury opens a 21-day practice window, while George Kittle is a distant (week-to-week) option for Week 6 with hopes for Week 7. SF will lean on depth as it prepares for the Buccaneers.

Kalia Davis exited with a hand injury in the second quarter of San Francisco’s Thursday night clash with the Rams, compounding an injury-plagued start to 2025 for the 49ers. With Davis questionable and Kevin Givens on IR, San Francisco could lean on Jordan Elliott, Alfred Collins, C.J. West and rookie Mykel Williams to anchor the interior. The late update confirmed Davis will miss the rest of the game, forcing a deeper rotation and more sub-packages against L.A.

Week 4 looks stabilized at quarterback for the 49ers as Brock Purdy nears a return from a toe injury, reducing major fantasy risk at the position. Mac Jones remains a questionable backup, but Purdy’s health is the backbone for San Francisco’s Week 4 upside.

In the receiving corps, Jennings and Pearsall carry injury risk. If both sit, Demarcus Robinson and Kendrick Bourne would step into lead roles, giving fantasy managers a late-week option with Robinson’s season debut on deck. Other listed veterans and depth pieces (Watkins, Green, West, Colby, Davis) create depth concerns more than fantasy pivots unless top WRs are sidelined.

Week 4 looming against Jacksonville keeps an eye on injuries as the key differentiator for lineups. Stay tuned to the final injury report and readiness news to gauge start/sit decisions for the 49ers’ pass game and potential DFS value.

Nick Bosa’s ACL injury tests the 49ers’ depth as rookies Mykel Williams, Alfred Collins, and CJ West join veterans Sam Okuayinonu and Yetur Gross-Matos in elevating the edge pressure. Kyler Murray and the Cardinals nearly drained the clock, with Upton Stout making a late impact. Trade chatter surrounds Trey Hendrickson as SF contemplates a path to continued pressure in 2025 and beyond. Trent Williams stabilizes the line, while Colby and Puni face a tough week-to-week grind. Kyle Shanahan’s injury updates frame a cautious, aggressive path forward that leans on youth developing under pressure.

Rookie development dominates SF’s narrative as the defense leans on a next-man-up approach. In pass protection, Luke Farrell shines while Colby’s five pressures highlight the volatility of new starters. The Hendrickson discourse—conditional picks and playoff incentives—embodies SF’s win-now tilt even with Bosa sidelined. Shanahan’s updates stress progression and scheme adaptability as the 49ers navigate a challenging early schedule.

Overall, SF’s strategy blends youth acceleration with veteran floor, aiming to keep pressure on the quarterback while the roster recalibrates around Bosa’s absence. The coming weeks will reveal which youngsters carry fantasy value and which veteran protections hold the line as SF seeks consistency without its star edge.