The San Francisco 49ers have made a significant roster move, waiving defensive lineman Drake Jackson. This decision comes after Jackson was unable to participate for the last season and a half due to a torn patellar tendon in his left knee, which ultimately led to his failed physical designation. Jackson, a second-round pick in the 2022 NFL Draft, had a promising start, recording six sacks in 23 games, with a standout performance in the 2023 season opener. However, the team's draft class that year has seen little success, with only quarterback Brock Purdy becoming a consistent starter.

In a bid to bolster their offensive line, the 49ers also signed former first-round picks Andre Dillard and Nicholas Petit-Frere. These additions are meant to provide competition for the swing tackle position behind starters Trent Williams and Colton McKivitz. Defensive depth was further enhanced by signing cornerback Dallis Flowers, while the team waved offensive lineman Jalen McKenzie and cornerback Tre Tomlinson due to injuries. Furthermore, the 49ers successfully signed seven of their eleven draft picks, indicating their commitment to building a strong roster for the upcoming season.

The Kansas City Chiefs maintained their perfect record by defeating the San Francisco 49ers 28-18, marking their sixth consecutive win of the season. The 49ers, plagued by injuries, struggled to keep pace with the Chiefs' aggressive defense and offensive plays.

Brock Purdy faced significant pressure, throwing three interceptions while Patrick Mahomes contributed with a rushing touchdown. Despite some bright moments from the 49ers, including a touchdown run by Purdy, they couldn't overcome the Chiefs' lead.

The Kansas City Chiefs continued their impressive start to the season with a 28-18 victory over the San Francisco 49ers, marking Patrick Mahomes' first 6-0 start as a starter.

Brock Purdy struggled against the Chiefs' defense, throwing three interceptions while managing to score two rushing touchdowns. The 49ers faced significant injury woes, losing Brandon Aiyuk to a potential ACL injury, adding to their list of unavailable players.

Despite the 49ers' efforts, including a solid performance from tight end George Kittle, the Chiefs' defense and Mahomes' dual-threat ability ultimately secured the win.

The San Francisco 49ers and Seattle Seahawks are battling injuries ahead of their Thursday Night Football game. The 49ers have officially placed safety Talanoa Hufanga on injured reserve due to ligament damage, sidelining him for four games. Kicker Jake Moody is also out with a high ankle sprain.

Other key players missing include defensive lineman Jordan Elliott and linebacker Demetrius Flannigan-Fowles. However, tight end George Kittle and linebacker Fred Warner are cleared to play. The Seahawks will also be without several starters, including Byron Murphy II and Riq Woolen.

In response to Hufanga's absence, rookie Malik Mustafa will step in at safety. Newly signed kicker Matthew Wright will handle kicking duties for the 49ers, who may also call up defensive linemen from the practice squad.