Mac Jones is set to start for San Francisco after a knee scare, with Adrian Martinez not elevated. Eli Apple was added from the practice squad for Sundays game against Jacksonville, signaling confidence in the rest of the depth chart. Ricky Pearsall and Jauan Jennings are questionable but likely to play, keeping Bourne, Robinson, Valdes-Scantling and Skyy Moore as viable targets if one sits. Colby is questionable; Moss or Zakelj could step in. Brandon Aiyuk’s absence remains the defining storyline for the offense.

If Pearsall and Jennings sit, the 49ers would lean on a shallow WR corps; if one plays, expect a broader distribution with the expected nod to Bourne and the Chiefs pairing of Robinson, Valdes-Scantling and Moore. The 49ers will list inactives 90 minutes before kickoff at Levi’s Stadium.

San Francisco’s interior line depth is being tested early. Ben Bartch’s high ankle sprain leaves the guard position thinner than anticipated, with Connor Colby questionable for Week 3. If Colby sits, Drew Moss and Nick Zakelj are poised to step in as potential starters, while Arizona presents a stiff Week 3 test for the reshuffled line. Fantasy managers should monitor Colby’s availability and Moss’s activation to gauge inside run game and protection against the Cardinals.

Ben Bartch’s high-ankle sprain sidelines the 49ers’ left guard, forcing the team to lean on a rookie and reshuffle the interior line as Week 2’s run game showed promise behind the left guard. Colby stepped up in Bartch’s absence and impressed, hinting he could secure the starting job if Bartch goes IR, with Moss or Zakelj as immediate practice-squad options.

Spencer Burford’s knee injury adds another layer of uncertainty, while Jauan Jennings’ ankle, Kyle Juszczyk’s concussion protocol, and Siran Neal’s concussion evaluation keep SF’s skill positions and blocking schemes in flux. Robert Beal joining the practice squad stabilizes depth, and Colby’s early success could free up the offense to lean on the run more efficiently as the season progresses.

Overall, SF is navigating an injuried-heavy week with a rookie stepping up, potential IR moves looming, and a handful of players in concussion protocol, all while aiming to maintain offensive pace behind a revamped front five and a broader receiving corps.