San Francisco’s Week 4 notes center on Brock Purdy’s toe soreness and a frontline that remains uneven despite Trent Williams’ game-high grade and Colton McKivitz’s solid run blocking. Purdy’s health clouds the offense as turnovers and red-zone shortfalls persist, even with a sharper screen game sparked by Colby Brendel and teammates on a key 21-yard TD. Special teams under the new coach still struggle, with Curtis Robinson’s whiff on a punt-return attempt emblematic of the ongoing unit-wide teething pains.

The rookie report highlights Colby Brendel’s tough outing, while Shanahan’s injury updates and Week 5 practice notes set the stage for a trip to Los Angeles and a Week 6 kickoff move against Tampa Bay. Fantasy managers should watch Purdy’s health, Williams’ inside-out blocking, and the evolving special-teams picture as lineup decisions tighten ahead of the Rams clash.

In short, Purdy’s health and the OL’s consistency shape the 49ers’ fantasy upside, with a defense that still supports a run-first approach despite early-season bumps.

In Week 4, the San Francisco 49ers’ Trent Williams faces a stern test from Jacksonville’s Josh Hines-Allen, a rising force who has sparked pressure in recent seasons. Williams has climbed back into the top tier after a rough start, while Hines-Allen’s 25.5 sacks over two seasons signals a surge in disruption. The clash could tilt the game’s outcome and reveal Williams’ remaining peak ability.

Beyond this duel, the piece notes the broader edge-war around San Francisco—Nick Bosa’s career benchmark versus Williams’ current form, and the varied styles of Granderson and Sweat as contrasting accelerants. The Week 4 matchup will illuminate Williams’ current ceiling and whether Jacksonville’s plan can erase his dominance or expose a potential decline.

Nick Bosa’s ACL injury tests the 49ers’ depth as rookies Mykel Williams, Alfred Collins, and CJ West join veterans Sam Okuayinonu and Yetur Gross-Matos in elevating the edge pressure. Kyler Murray and the Cardinals nearly drained the clock, with Upton Stout making a late impact. Trade chatter surrounds Trey Hendrickson as SF contemplates a path to continued pressure in 2025 and beyond. Trent Williams stabilizes the line, while Colby and Puni face a tough week-to-week grind. Kyle Shanahan’s injury updates frame a cautious, aggressive path forward that leans on youth developing under pressure.

Rookie development dominates SF’s narrative as the defense leans on a next-man-up approach. In pass protection, Luke Farrell shines while Colby’s five pressures highlight the volatility of new starters. The Hendrickson discourse—conditional picks and playoff incentives—embodies SF’s win-now tilt even with Bosa sidelined. Shanahan’s updates stress progression and scheme adaptability as the 49ers navigate a challenging early schedule.

Overall, SF’s strategy blends youth acceleration with veteran floor, aiming to keep pressure on the quarterback while the roster recalibrates around Bosa’s absence. The coming weeks will reveal which youngsters carry fantasy value and which veteran protections hold the line as SF seeks consistency without its star edge.