Brock Purdy is inactive for Week 3 as San Francisco lists six inactives, including Jauan Jennings and Jordan Watkins. The 49ers must navigate the Arizona Cardinals at Levi’s Stadium with a backup quarterback and a thinner receiving corps. Kickoff is 4:25 p.m. ET on FOX. The absence of Purdy shifts the game plan toward the run game and reserve options, elevating fantasy risk and opportunity for others on SF and for Cardinals defenders in deeper formats.

Week 3 injury updates put the San Francisco 49ers in a bind as Brock Purdy's availability for Sunday’s game against Arizona remains highly uncertain. Purdy is limited all week with toe/left shoulder issues and is unlikely to start, elevating the importance of depth at guard and receiver. Connor Colby’s groin and Jauan Jennings’ ankle/shoulder further thin the lineup, while Jordan Watkins’ calf adds another notch to the injury narrative. McCaffrey carries a heavier burden, backed by a rest-conscious defensive plan and a few uncertain blockers. On the other sideline, the Cardinals list a handful of doubtful or limited players up front and in the secondary, setting the stage for a Week 3 test of depth and game plans.

Arizona hosts San Francisco in Week 3 with a crowded injury report. Will Johnson DNP groin; Melton limited with a knee; Beachum, Hernandez, Paris Johnson Jr, Reiman, Simon and Stills limited or resting concerns; Jordan James back to full participation with a finger issue. The Cardinals eye a 3-0 start while juggling depth and playmakers.

San Francisco faces a similar test with eight DNPs on the list but Brock Purdy back in limited action as he finishes toe and shoulder rehab. With Nick Bosa resting and Christian McCaffrey dealing with a calf/rest, Kyle Shanahan will lean on creative wrinkles. Kyler Murray notes Levi’s Stadium vibe as a factor in this NFC West clash.