Kalia Davis exited with a hand injury in the second quarter of San Francisco’s Thursday night clash with the Rams, compounding an injury-plagued start to 2025 for the 49ers. With Davis questionable and Kevin Givens on IR, San Francisco could lean on Jordan Elliott, Alfred Collins, C.J. West and rookie Mykel Williams to anchor the interior. The late update confirmed Davis will miss the rest of the game, forcing a deeper rotation and more sub-packages against L.A.

Mizzou’s NFL alumni show a broad spectrum across the league, from steady role players to breakout flashes. Armand Membou anchors the Jets’ offense with a 74.3 PFF grade on 180 snaps, while Luther Burden III flashed a big Week 3 line and a 74.7 grade on limited work. Several scatter for reps or deal with injuries, but the depth is rich for DFS and deeper leagues as roles evolve.

Arizona’s Darius Robinson and Cleveland’s Isaiah McGuire stand out for their respective defenses, with Robinson grabbing a sack and McGuire grading well against the run. Denver’s Tyler Badie and Green Bay’s Ty’Ron Hopper hint at longer-term upside if usage shifts occur. The mix of injuries, development, and coaching notes creates a dynamic map for fantasy managers to navigate in coming weeks.

Nick Bosa’s ACL injury tests the 49ers’ depth as rookies Mykel Williams, Alfred Collins, and CJ West join veterans Sam Okuayinonu and Yetur Gross-Matos in elevating the edge pressure. Kyler Murray and the Cardinals nearly drained the clock, with Upton Stout making a late impact. Trade chatter surrounds Trey Hendrickson as SF contemplates a path to continued pressure in 2025 and beyond. Trent Williams stabilizes the line, while Colby and Puni face a tough week-to-week grind. Kyle Shanahan’s injury updates frame a cautious, aggressive path forward that leans on youth developing under pressure.

Rookie development dominates SF’s narrative as the defense leans on a next-man-up approach. In pass protection, Luke Farrell shines while Colby’s five pressures highlight the volatility of new starters. The Hendrickson discourse—conditional picks and playoff incentives—embodies SF’s win-now tilt even with Bosa sidelined. Shanahan’s updates stress progression and scheme adaptability as the 49ers navigate a challenging early schedule.

Overall, SF’s strategy blends youth acceleration with veteran floor, aiming to keep pressure on the quarterback while the roster recalibrates around Bosa’s absence. The coming weeks will reveal which youngsters carry fantasy value and which veteran protections hold the line as SF seeks consistency without its star edge.

James Conner’s season-ending ankle injury against the 49ers forces a backfield pivot in Arizona, with Trey Benson primed to lead. Benson finished Week 3 with 51 yards from scrimmage and has been climbing into a larger workload, hinting at a potential breakout as the primary back for the rest of the season. Conner’s durability history—knees, lymphoma in college, and a recent lingering knee issue—adds urgency to Benson’s opportunity and makes his path to a heavy workload plausible.

Conner’s past injuries and the timetable surrounding his exit place extra emphasis on Benson’s Florida State pedigree and his three-game early-season trajectory. Benson’s emergence could reshape Arizona’s fantasy profile, especially in PPR formats where his involvement as a receiver matters. On the other side, San Francisco’s defense and the surrounding injury chatter—like Nick Bosa’s ACL scare despite Shanahan’s optimism—keep the Week 3 results meaningful for buyers and sellers heading into the next slate of games.

James Conner’s Week 3 leg injury forces Arizona to rework its rushing game, leaning on Emari Demercado, Trey Benson and Greg Dortch. Najee Harris’s Achilles injury for the Chargers adds another season-altering blow to LA’s backfield, widening the gap for backups. The hit that sidelined Conner came from Jordan Elliott of the 49ers, with Marques Sigle involved, underscoring how quickly depth can alter fantasy value in early-season weeks.