The Rams aim to throttle Christian McCaffrey again after silencing Barkley and stifling Taylor, with a division showdown against San Francisco looming. Purdy’s toe injury tightens the game plan while Mac Jones steps in for the 49ers, elevating the pressure on McCaffrey as the focal point of a banged-up offense. A Rams win would push them into first in the NFC West and validate their recent run-stopping form on the road to a Thursday night clash.

Fantasy angles hinge on McCaffrey’s usage as the centerpiece and the turnover risk with Purdy sidelined. Expect a heavy dose of McCaffrey as the game’s engine, plus how well the Rams’ pass rush contends with a devoutly run-first SF scheme. Injuries to Kittle and key receivers could tilt targets toward McCaffrey and the 49ers’ short-pass game, shaping weekly lineups and DFS decisions.

Week 4 looks stabilized at quarterback for the 49ers as Brock Purdy nears a return from a toe injury, reducing major fantasy risk at the position. Mac Jones remains a questionable backup, but Purdy’s health is the backbone for San Francisco’s Week 4 upside.

In the receiving corps, Jennings and Pearsall carry injury risk. If both sit, Demarcus Robinson and Kendrick Bourne would step into lead roles, giving fantasy managers a late-week option with Robinson’s season debut on deck. Other listed veterans and depth pieces (Watkins, Green, West, Colby, Davis) create depth concerns more than fantasy pivots unless top WRs are sidelined.

Week 4 looming against Jacksonville keeps an eye on injuries as the key differentiator for lineups. Stay tuned to the final injury report and readiness news to gauge start/sit decisions for the 49ers’ pass game and potential DFS value.