Purdue has 14 alumni on NFL rosters for the 2025 season, led by George Karlaftis in Kansas City. Aidan O’Connell and Raheem Mostert link up for the Raiders, while Tyrone Tracy Jr. and Marcus Mbow may pair again with the Giants. Charlie Jones, Payne Durham, Derrick Barnes, Sanoussi Kane, Rondale Moore, David Bell, Cory Trice Jr., Jalen Graham, and Reese Taylor are scattered across the league, offering depth and late-round fantasy/IDP upside across Bengals, Buccaneers, Lions, Ravens, Vikings, Browns, Steelers, 49ers, Giants, and Broncos.

The Purdue pipeline continues to influence dynasty and streamer decisions, with injury notes, camp chatter, and depth-chart shifts shaping how owners value Purdue-affiliated players in the weeks ahead. Stakeholders should monitor IR statuses for O’Connell, backfield splits in Vegas, and Giants’ backfield competition as the season unfolds.

San Francisco trimmed to 53, releasing William Bradley-King and Chazz Surratt and waiving Jalen Graham as roster cuts loom. Bradley-King, a seventh-rounder with stints in DC, New England and Miami, was near the back of a crowded edge group. Surratt, a North Carolina standout with All-ACC and All-American honors, came up short in his bid for a reserve LB role after returning in May. Graham, Purdue product and 2023 draftee, was also released.

These moves thin San Francisco’s depth behind stars and could push younger players into preseason reps, with fantasy managers watching for any quick risers in the edge/LB mix. The team has a high-quality defense, but the cuts emphasize competition for reserve snaps and potential practice-squad elevations.

The San Francisco 49ers face challenges ahead of their matchup against the Green Bay Packers, with offensive lineman Jon Feliciano officially ruled out due to a knee injury. Feliciano, who recently signed a one-year extension, has yet to play this season after starting on injured reserve.

In a positive turn, the 49ers have promoted veteran safety Tashaun Gipson Sr. to the active roster. Additionally, linebacker Jalen Graham and cornerback Nick McCloud have been activated from the practice squad. Key players like Trent Williams and Brock Purdy remain questionable or out for the game.