San Francisco faces a Thursday-night test at the Rams with Brock Purdy sidelined and multiple starters out, triggering a noticeable pullback in ticket demand. Market data shows the minimum price dipping from about $199 to $130 and the average from roughly $564 to $345 as injury news swirls. Fantasy aside, SF’s high-end offense takes a hit with Pearsall, Jennings, Aiyuk, Kittle, and Bosa out or uncertain, shifting the game’s narrative toward backups and Rams defenders in a tricky week-early matchup.

George Kittle’s hamstring injury in Week 1 landed him on IR, pushing his return to Week 6 at the earliest. Fantasy managers should anticipate a TE1 restart as San Francisco’s passing game stabilizes behind Brock Purdy, with Brandon Aiyuk sidelined and Jauan Jennings and Ricky Pearsall dealing with injuries.

Back on the field, Kittle steps into a reshuffled but high-upside target tree. If he stays healthy, the matchup-proof tight end can reclaim top-tier weekly upside and help unlock a more efficient 49ers aerial attack as the surrounding pieces work their way back.

The broader health of Purdy and the receivers could influence Kittle’s immediate workload, but his talent remains a clear path to elite fantasy production the moment he returns.

In San Francisco, injury chaos defined a tense day as the 49ers navigated a rough setback with key health scares. Jauan Jennings absorbed a rib‑shot during a two‑point try and sat under a blue medical tent while Ricky Pearsall waited for evaluation on a knee issue. The scene echoed earlier Week 1 delays, and with George Kittle and Brandon Aiyuk sidelined and Nick Bosa lost for the season, the offense and defense are leaner as they chase a 26‑21 loss.

The strain on depth depthened as Pearsall exited late the third, Jennings returned, and the 49ers pressed on without two of their top playmakers. This mix of injuries creates a shifting target share and a tougher path for fantasy managers monitoring San Francisco’s receivers and overall game flow as the season unfolds.