Spencer Burford’s knee injury lands him on IR, thinning San Francisco’s interior O-line and nudging Austin Pleasants into a swing-tackle role ahead of Week 3 against Arizona. Ben Bartch is already on IR, so depth is tested. Adrian Martinez is elevated again at QB, but Brock Purdy remains the likely Week 3 starter with a toe issue, while Martinez isn’t active. Malik Turner is also elevated to bolster WR depth as Jordan Watkins deals with a calf injury and Jauan Jennings is questionable. That mix limits risk and upside for SF’s pass attack and run game in a pivotal road matchup.

Martinez’s elevation signals QB depth without promising immediate playtime; Purdy’s health matters most for fantasy, while Turner’s addition provides a potential fourth-down target behind Deebo Samuel and George Kittle. The Cardinals loom with a defense capable of pressure, so SF will lean on quicker throws, a stable run game, and protection tweaks to navigate the Week 3 challenge.

San Francisco’s interior line depth is being tested early. Ben Bartch’s high ankle sprain leaves the guard position thinner than anticipated, with Connor Colby questionable for Week 3. If Colby sits, Drew Moss and Nick Zakelj are poised to step in as potential starters, while Arizona presents a stiff Week 3 test for the reshuffled line. Fantasy managers should monitor Colby’s availability and Moss’s activation to gauge inside run game and protection against the Cardinals.