The San Francisco 49ers have placed star wide receiver Brandon Aiyuk along with five others on the Active/Physically Unable to Perform (PUP) list ahead of the 2025 training camp. Aiyuk, who is recovering from major knee injuries sustained during last season's Week 7 matchup against the Kansas City Chiefs, will miss the start of training camp and could potentially miss the beginning of the upcoming season. Joining him on the PUP list are offensive tackle Andre Dillard, defensive lineman Yetur Gross-Matos, safety Malik Mustapha, wide receiver Ricky Pearsall, and linebacker Curtis Robinson.

This decision leaves the 49ers with a significant gap in their roster, particularly at wide receiver, as Aiyuk has been a crucial part of their offensive strategy. His recovery will be closely monitored as the team prepares for the season. The absence of such key players during training camp could impact the team's development and strength going into the regular season.