Kyren Williams posted 64 rushing yards, 66 receiving yards, and 2 TDs, and his TD celebration drew a pointed Instagram response from Deommodore Lenoir, escalating the Rams-49ers clash.

San Francisco edged Los Angeles 26-23 in overtime, and the Week 10 rematch figures to heighten drama and sharpen fantasy lenses on Williams’ dual-threat role and Lenoir’s coverage matchup.

Williams' versatility keeps him viable in standard and PPR formats, while Lenoir's public stance adds psychological edge that could influence the next meeting and how defenses defend Williams and Stafford.

The 49ers’ Week 5 win over the Rams rode on a chaotic OT stop after a steady defensive push and a late, gritty performance by the squad’s supporting cast. Mykel Williams didn’t post a stat line but drew the eye with a game-changing edge step that opened the winning path for Warner, while Marques Sigle and Deommodore Lenoir held the back end together in a tense finish. Offensively, SF leaned on McCaffrey’s blocking and Purdy’s health narrative, with Mac Jones stepping in as a surprise producer in the quarterback shuffle. Trade chatter swirls around Hendrickson as the front office weighs a playoff push, and the team braces for Kittle’s potential absence while Malik Mustapha nears return. Fantasy takeaway: depth and health emerge as pivotal in a league where one big name can be out, one backup can step up, and defensive pressure can tilt outcomes in high-leverage moments.

Shanahan’s crew showed resilience, especially up front and in coverage, highlighting the IDP and streaming options for Week 6. Williams’ quiet stat line belies a fingerprints-on-the-game impact, while Sigle’s 13 tackles underscore the importance of safeties who can mix run support with coverage. The QB landscape remains fluid: Purdy’s health versus Jones’ hot run creates a dual-path for fantasy rosters, with Hendrickson potentially altering the defensive ceiling if a trade materializes. Monitor Kittle’s status, monitor Purdy’s health, and keep a pulse on the 49ers’ evolving depth chart as the schedule thickens.

San Francisco survived a Thursday with Purdy sidelined, Mac Jones thriving in relief, and a dramatic OT win over Los Angeles. Kyren Williams’ 4th-and-1 fumble loomed large, reshaping the late game, while the 49ers leaned on depth and defense as reinforcements prepare to return. The Rams still loom, but questions about red-zone calls and ball security linger as the NFC West race tightens.

Fantasy takeaways center on Williams’ reliability, Corum’s red-zone potential for LA, and SF’s risk-reward with Jones at the helm. Health will decide seeds—Kittle, Aiyuk, Pearsall, and Bosa looming back—keeping SF in the top mix while the Rams chase leverage in a tougher schedule.