Isaac Guerendo has shown potential as a running back with the San Francisco 49ers, proving to be a valuable asset when called upon last season. His performance, highlighted by a commendable average of 5.0 yards per carry, indicates his ability to capitalize on opportunities, especially during injury spells for the main roster players. As a backup to the star Christian McCaffrey, Guerendo's upside shines through, making him a player to monitor for fantasy leagues in 2025.

With McCaffrey's history of injuries, Guerendo could step into a larger role, offering fantasy managers an intriguing option should the need arise. His performance last season positions him as a potential starter, making him a worthy consideration in deeper leagues or as a handcuff in standard formats.