The San Francisco 49ers made significant strides in the 2025 NFL Draft, amassing 11 picks and securing notable talent. ESPN's Matt Miller identified four of these selections among his top 100 draft fits, highlighting the potential impact these players could have on the team. First-round pick Mykel Williams from Georgia, praised for his impressive college stats, was noted as a strong fit at No. 38. Defensive tackle C.J. West (Indiana), wide receiver Jordan Watkins (Ole Miss), and running back Jordan James (Oregon) also made the list, showcasing the team's commitment to enhancing its roster.

Mykel Williams, a 6-foot-5 edge rusher, could thrive alongside All-Pro Nick Bosa, while C.J. West is framed as a developmental starter with a solid collegiate resume. Watkins brings speed and route-running prowess, and James is expected to step in as a key contributor after Jordan Mason's trade. The 49ers' strategic picks reflect their focus on bolstering their defensive and offensive lines, positioning themselves for future success in the competitive NFL landscape.