The San Francisco 49ers made a significant impact during the 2025 NFL Draft, utilizing all 11 of their picks to bolster their roster with a focus on defensive prowess. Key selections include DT CJ West, who, despite starting as a backup, is anticipated to enhance the defensive line’s depth immediately. The 49ers also secured S Marques Sigle, regarded as a versatile player capable of filling multiple roles in the secondary, potentially as a Day 1 starter. Other noteworthy choices were DE Mykel Williams and DL Alfred Collins, aimed at strengthening the front seven, which had been a critical area of need.

The remainder of their draft focused on adding depth at key positions, with RB Justin James and OL Connor Colby expected to contribute as role players. The 49ers also took a chance on QB Kurtis Rourke, who brings potential upside despite recovering from injury. Overall, this draft reflects a strategic effort to enhance the squad's competitiveness and address previous shortcomings, with an eye on making a deep playoff run in the upcoming season.