The San Francisco 49ers made significant strides in the 2025 NFL Draft, acquiring 11 new players to bolster their roster. Among these selections, defensive end Mykel Williams is projected to step into a starting role, significantly enhancing the team’s run defense. Alfred Collins, selected in the second round, is poised to add depth to the defensive line. Linebacker Nick Martin, a third-round pick, has a chance to secure the Will linebacker position, while Upton Stout, drafted as a cornerback in the same round, could play a vital role in the slot. Players like Jordan Watkins and Marques Sigle will compete for positions in a crowded receiving corps and secondary respectively, while running back Jordan James could emerge as a dependable option behind Christian McCaffrey. The 49ers also secured valuable depth with several late-round selections, including quarterback Kurtis Rourke and offensive lineman Connor Colby, setting the stage for an exciting training camp.