Jacksonville escaped San Francisco with a road upset, climbing to 3-1 and sharing the AFC South lead with Indianapolis. The defense forced four Purdy/McCaffrey turnovers and the Jaguars dominated the trenches, piling 151 rushing yards on 4.7 per carry while allowing zero sacks.

In the edge game, Bryce Huff was neutralized as Mykel Williams and Sam Okuayinonu out-snapped him, prompting questions about Shanahan’s rotation with Nick Bosa out for the season. The result deepens fantasy intrigue around Lawrence, Etienne, and a suddenly stout Jags defense, while SF faces questions about their pass rush without their star.

Nick Bosa's ACL tear creates a massive void for the 49ers, forcing a by-committee pass rush and new schematics. Kyle Shanahan stresses that no one can truly replace a star like Bosa, so the defense must elevate everyone and accelerate development across the board.

Rookies and veterans—Mykel Williams, Bryce Huff, Yetur Gross-Matos, and Sam Okuayinonu—will share load, with perhaps more blitzing from Robert Saleh's approach and more emphasis on linebackers and the secondary in coverage and pressure. Fantasy angles point to uncertainty up front but growing defensive versatility.

Expect shifting snap shares and evolving game plans as San Francisco navigates the season without a single anchor on the edge, making early-season production a moving target for fantasy managers and bettors alike.

Nick Bosa’s season-ending ACL injury rocks the 49ers’ defense and reshapes fantasy projections. Huff, already making strides, will be the focal point for offenses, risking diminished impact as teams key on him. Mykel Williams’ breakout pace may slow under extra attention, even as he offers inside pressure that could keep the edge duo effective. San Francisco must lean on depth, scheme, and Williams’ interior rush to preserve a stout D while fantasy managers adjust expectations for sacks and reps.

Nick Bosa's season-ending ACL tear forces San Francisco to reshuffle their defense without the premier edge. Williams and Huff must absorb a larger rush load, while Saleh leans on the lockdown corners to keep coverages tight. Offense health improves, giving the 49ers a fighting chance to stay high-scoring and give the defense room to adapt.

The plan mirrors past adjustments: rely on shutdown coverage and scheme tweaks if the edge collapses, and lean on a healthier offense to control game tempo. For fantasy managers, Williams and Huff become top targets, with offense-driven upside as long as health holds.

Bottom line for fantasy: monitor how SF scripts games without Bosa. If Williams and Huff rise quickly, they become must-ros for DFS and dynasty. If the defense struggles in certain matchups, opponents may chase more points against SF, reshaping weekly projections.