Mac Jones reconnects with Kendrick Bourne as Brock Purdy misses time, placing Bourne in a crucial Week 2 role for the 49ers and tightening the swing from Jones to SF’s new-season targets. The Saints’ Week 1 jitters and a mobile Spencer Rattler complicate SF’s game plan, but Bourne’s familiar chemistry could yield a clean, high-floor target in a tough road matchup.

New Orleans showed a rough debut under Moore, piling up penalties while leaning on Kamara and Miller in the run game. SF’s defense must contend with Rattler’s movement and Saints’ ground game, setting up SF to capitalize if the breakdowns linger and Bourne delivers as a reliable outlet in Jones’s limited-but-possible Week 2 volume.

Week 1 spreads crushed, but totals stalled as the Panthers misfired and Jets-Steelers stayed under. Week 2 pivots to sides over totals, targeting teams with short spreads or high totals (45+), plus a lean into teams that can blow out opponents. Five top bets: Lions -6 vs Bears; Eagles -120 at Chiefs; 49ers -3 at Saints; Jaguars +3.5 at Bengals; Seahawks +3 at Steelers.

Player props include Trey Benson Over 34.5 rushing yards, Matthew Stafford Under 32.5 pass attempts, J.J. McCarthy Over 16.5 rushing yards, plus TD bets on Brian Thomas Jr., A.J. Brown, and David Montgomery. Three red flags: Cowboys, Cardinals, Broncos. Turn on alerts with SportsLine for deeper insights.