Week 2 survival pools collide with brutal SF injuries as Purdy, Kittle and Aiyuk sit or are limited, leaving the 49ers vulnerable in New Orleans. SF still sits as a small road favorite, but the model-backed winner is not the favored San Francisco slate. Across the board, Browns, Lions, Bills, Rams, and Panthers offer the most reserve-friendly routes in a week light on obvious chalk. The advanced projection behind SportsLine leans hard toward a non-SF winner in Week 2, a rare call that could redefine typical survivor play.

With Purdy out and SF retooling, the model shifts toward a high-probability, yet less obvious, Week 2 path and urges readers to check its pick for the exact play. New users can claim promo bonuses while studying the model’s 10,000-simulations and continued track record. The takeaway: trust the numbers, not just the eye test, in a Week 2 full of injury-driven pivots.