Week 2 injury window tightens fantasy outlooks: George Kittle lands on IR with a hamstring strain, likely sidelining him through Week 5–6, pushing TE targets to Tonges, Farrell, and the surrounding 49ers receivers. Brock Purdy is out 2–5 weeks with turf toe, so Mac Jones steps in Week 2 with Pearsall steady as a WR2 and Jennings as a flex option. Xavier Worthy is doubtful for Week 2 with a shoulder dislocation, boosting Brown, JuJu, and Kelce. Brock Bowers deals with a knee and could miss or play, forcing Mayer into a potential starter role if he sits. Stash Kittle and Purdy where you can, monitor Bowers, Worthy, and Mayer, and adjust rosters with a contingency mindset.