San Francisco’s Week 2 outlook mirrors last year’s early-season chaos: Purdy sidelined by turf toe, Kittle on IR, and a thinning receiving corps. McCaffrey becomes the offense’s anchor as Mac Jones runs the show, while Aiyuk is out on PUP and Jennings is banged up. A wave of veterans rests or is injured, elevating depth players in SF’s plan. The Saints test a cautious game plan with heavy run usage and stout defense, creating upside for SF’s backfield and opportunistic deeper targets in fantasy.