SF opened Week 1 versus Seattle with two practice-squad promotions at WR/linebacker—Russell Gage and Curtis Robinson—while not promoting a running back. Marques Valdes-Scantling joined the active roster earlier, and Ricky Pearsall plus Jauan Jennings figure into a crowded receiver mix alongside Sky Moore as Seattle looms. With Christian McCaffrey likely suiting up, SF relies on a lean backfield (McCaffrey, Brian Robinson Jr., Isaac Guerendo) and a special-teams boost from Robinson.

Fantasy takeaway: expect role-sharing among SF receivers, with Gage and Pearsall offering floor upside if targets swing in their direction. McCaffrey anchors the offense, while the reserve RBs are situational—limit expectations for immediate backfield volume unless injuries surface early.