Drake Jackson's NFL career faced a significant setback when the San Francisco 49ers waived him following a failed physical due to a serious patellar tendon injury. Drafted in the second round of the 2022 draft, Jackson was expected to bring speed and agility to the 49ers' defense, especially alongside All-Pro Nick Bosa. However, persistent injuries, including previous knee and quadricep issues, have limited his impact, resulting in only 23 games played and a placement on the reserve/physically unable to perform list for the 2023 season.

Initially praised for his athleticism at USC, Jackson's potential has been overshadowed by concerns over his technique and ability to counter stronger opponents in the NFL. He now shifts focus to rehabilitation, with hopes of rejoining the team for training camp next season.