San Francisco’s 2025 practice squad spotlights camp standouts and a pair of likely signings who could swing fantasy odds this year. Adrian Martinez, Sincere McCormick, Robbie Chosen, Drake Nugent and Eli Apple anchor a depth chart built to contribute behind the active roster, with Nugent and Nick Zakelj adding interior line flexibility and Chosen offering veteran pass-catching upside. This mix signals SF’s plan to weather injuries and suspensions, a smart angle for fantasy managers tracking late-season surges.

For fantasy and bets, Martinez and McCormick stand out as potential late-season inputs, while Nugent and Apple provide stabilizing floor for SF’s rotation. Bergen’s presence adds a special-teams lift, and Nugent’s preseason showing hints at a longer arc for interior depth. Watch how SF leverages this group when Week 1 rolls around and injuries test the depth chart.