San Francisco remains a heavy playoff favorite (-196) after a 6-11 season, with FanDuel putting playoff odds at 62.8%. The optimism hinges on a friendly schedule and a high-end core that includes McCaffrey, Kittle, Williams, Bosa, and Warner staying healthy. Worries loom over a depleted wide-receiver corps and trenches, plus a competitive NFC West, but a strong finish could push SF back to the postseason.

Fantasy angles lean on SF’s stars delivering when health cooperates and the WR depth stabilizes. If the Niners minimize one-score losses and leverage a soft early slate, they should rebound to playoff contention, while a few close games swing big in fantasy lines for McCaffrey, Kittle, and Warner.