Week 1 features the NFC West’s fiercest clash as the 49ers visit Seattle. San Francisco arrives with a healthy, star-studded offense led by Purdy and friends McCaffrey, Aiyuk, and Kittle, aiming to remind the league their championship window is still wide open. Seattle counters with a revamped attack under a new scheme and Darnold at the helm, with Jaxon Smith-Njigba ready to spark the offense.

Expect a physical, sometimes messy opening half, then SF’s depth, coaching edge, and playmakers pull away. Smith-Njigba could provide the Seahawks a meaningful spark with 70+ receiving yards and a TD, while Purdy, McCaffrey, and Kittle anchor a late surge for the visitors.