Brock Purdy's turf toe has him limited at practice with a real chance to play Week 3 against Arizona. Shanahan will gauge reps to reintegrate him, a step SF needs after a banged-up 2024 and George Kittle being on IR. Mac Jones filled in Week 2 and SF won, but Purdy's health remains the keystone for fantasy value and divisional plans.

If Purdy suits up, expect SF to blend quick passes with a steady run game, keeping targets spread but leaning on McCaffrey and the receiving corps. If he sits, Jones or a scaled-back script could shift the offense, lifting or lowering fantasy upside across the lineup as SF guards Purdy's timetable.

The Week 3 matchup vs Arizona becomes a litmus test for Purdy's timetable and the offense's staying power as SF navigates a tough division; the team’s depth and return timeline will shape weekly fantasy projections far beyond this week.