Guerendo, Bateman, and Deebo Samuel Sr. headline Week 1 starts, with Guerendo viable as a high-end RB3/flex if McCaffrey sits. Bateman is a cautious WR3 with upside in a Bills game, thanks to his 13.9 aDOT but fluctuating targets. Samuel Sr. lands in Washington with a potently improved surrounding cast, offering a high-ceiling WR3/Flex.

Guerendo flashed in limited snaps, averaging 17.9 PPR in a 4-game stretch; if McCaffrey sits, he could see 15–20 touches. If not, Brian Robinson remains the backfield leader, capping Guerendo's workload. Bateman’s extension stabilizes the role, but the Bills defense keeps his floor modest. Samuel Sr. should thrive in Washington’s fast-paced environment, yielding weekly upside as a top secondary option.

Bottom line: monitor McCaffrey, injuries, and the opponent to decide Week 1 starts for these three — Guerendo in deeper formats, Bateman as a risky WR3, and Samuel Sr. as a strong flex option when healthy.