Jauan Jennings cleared in final MRI and expected to play Week 1 against Seattle, though SF will ease him into practice. With Brandon Aiyuk on the PUP and Jacob Cowing IR, Jennings would anchor SF’s top two receivers alongside George Kittle and Christian McCaffrey, lifting the passing game floor if he’s healthy enough to contribute. If Jennings is limited, depth options like Ricky Pearsall, Jordan Watkins, and Jacob Cowing could absorb added targets in a potential high-volume opener.

Jennings’ career-best 77 receptions, 975 yards, and six TDs set a high bar for Week 1 expectations. Seattle’s Week 1 test will hinge on practice progression and game flow, shaping target distribution and the fantasy upside of SF pass-catchers. Managers should map Jennings’ role to practice status and Seattle’s coverage to set accurate lineups.