Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.