San Francisco trims from 90 to 53 by Tuesday, with two players likely landing on IR with return designations to free rosters. Jacob Cowing hamstring could miss 6-8 weeks, Kevin Givens pectoral injury signals deeper roster questions. Most exits hit waivers, then practice squad options; early cuts may surface with veterans, while the 53-man tally shapes the WR and interior DL depth after a 30-23 preseason win over the Chargers.